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While the precise mechanisms remain incompletely understood, these neurons exhibit particular vulnerability to oxidative stress due to their high basal metabolic activity, autonomous pacemaking requiring intense calcium cycling, and ROS generation during dopamine metabolism [187]

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Julia Ljubimova of Cedars-Sinai Medical Centre in Los Angeles and her colleagues found that Viagra (sildenafil) and Levitra (vardenafil), which inhibit an enzyme called phosphodiesterase 5 (PDE5), increased the permeability of the blood-brain barrier